When you want delicious, authentic Mexican food, fast friendly service, the BEST margaritas, and a fun-filled atmosphere, come to Medrano's!!! Our Locations Lancaster 44276 10th Street West Lancaster, CA 93534 661-948-4247 West Palmdale 1173 West Rancho Vista Blvd Palmdale, CA 93551 661-224-1145 Quartz Hill 5037 Ave N, Suite 19 Quartz Hill, CA 93536 661-718-1305 Santa Clarita (coming soon) 19319 Soledad Canyon Road Santa Clarita, CA 91351 661-367-4945 Menu We have all your favorites! Tacos, enchiladas, burritos, fajitas, tostadas, ceviche, mole, chile verde, carne asada, arroz con pollo, quesadillas, nachos, and more. View Printable Menu Banquets & Catering Are you having a party? You can bring your group to Medrano's, or we can bring our food (and awesome staff members) to you! We have delicious meal options for almost every budget. Contact Us What's Happening at Medrano's? Join in the fun at our Cinco de Mayo celebrations at our Lancaster and West Palmdale locations!